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Thischapter was written to provide the reader with a general over-view of both, the basic biology involved in the induction ofmutation and how mutation is involved in human disease, thusproviding a context for the importance of genetic toxicology inthe general field of toxicology. It has the ability tocarry solutes into the skin from which they are slowlyreleased into the blood and lymph. HLA-B27 canbe present in 8 percent of the general population and is not necessary to confirm a diag-nosis of AS. The cemented(or frozen in place) stapes does not vibrate and preventssound waves from reaching the perilymphatic fluid spaceof the internal ear, causing conductive hearing loss

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